1. Director, AI Experience and Workflow Design — Pfizer

Company: Pfizer
Location: New York City, NY
Level: Director
Salary: $163,000–$272,000 annually

Pfizer is hiring a Director, AI Experience and Workflow Design to lead UX and experience architecture for AI-powered platforms within Medical Affairs.

The role focuses on designing AI-enabled workflows, agent behavior, human-in-the-loop models, interfaces, prototypes, and design standards.

The position also emphasizes usability testing, success metrics, stakeholder collaboration, and enterprise-scale transformation.

Key skills include:

This is particularly relevant for experienced UX and product designers interested in applying AI to complex enterprise and healthcare workflows.

2. Staff Product Designer — Legora

Company: Legora
Location: New York City, NY
Level: Staff / Senior
Salary: $240,000–$316,000 annually

Legora is hiring a Staff Product Designer for its AI-powered legal technology platform.

The role involves designing complex legal workflows, influencing product strategy, collaborating with product and engineering teams, and exploring AI-driven design approaches.

The advertised compensation range makes this one of the higher-paying design opportunities currently appearing in the NYC AI-design market.

Key skills include:

3. AI Product Designer — Onebrief

Company: Onebrief
Location: New York, NY
Work model: Remote
Level: Senior
Salary: $160,000–$230,000 annually

Onebrief is hiring an AI Product Designer focused on AI-enabled workflows for military planning and operational coordination software.

The designer owns UX definition for a product area, conducts user research, maps workflows, develops design patterns, and evaluates emerging AI UX patterns.

The role also involves documenting design intent for both people and AI tools.

Key skills include:

This is a strong example of how AI design is expanding into highly specialized enterprise workflows.

4. Senior Product Designer — FloQast

Company: FloQast
Location: New York, NY
Level: Senior
Salary: $144,000–$216,000 annually

FloQast is hiring a Senior Product Designer to work on SaaS products that incorporate AI capabilities for accounting professionals.

The designer will translate complex AI capabilities into intuitive and trustworthy experiences while working across research, analytics, prototyping, product strategy, and implementation.

Key skills include:

The role is a useful example of how AI is becoming embedded into traditional enterprise software rather than existing only inside standalone AI products.

5. Director, Product Design — AI Experience — AlphaSense

Company: AlphaSense
Location: New York City / Remote
Level: Director or Senior Director

AlphaSense is building an AI-native, agentic product for financial research and intelligence.

The company is looking for a design leader to define the UX direction for its AI experience and lead a team of senior designers.

The role specifically involves challenges such as:

Designers working on this type of product need to think beyond conventional screens and consider how people interact with AI throughout an entire workflow.

6. Product Designer — Outtake

Company: Outtake
Location: New York City, NY
Level: Product Designer
Work model: In-office

Outtake is building an agentic AI platform focused on detecting and responding to impersonation, fraud, AI-driven scams, and identity abuse.

Its Product Designer role was posted on September 14, 2026, making it one of the newer AI-focused design opportunities appearing in NYC this month.

The company is looking for strong interaction, visual, and motion design skills. Experience with AI, automation, agent-based systems, cybersecurity, trust and safety, and AI tools is valuable for the role.

Key skills include:

7. Design Engineer — Confido

Company: Confido
Location: New York, NY
Level: Mid-level
Salary: $150,000–$180,000 annually

Confido is hiring a Design Engineer to work across product design and frontend implementation for a B2B platform.

The role combines traditional product design with the ability to refine validated designs directly in code.

It also specifically highlights the use of AI coding tools, including Claude Code and Cursor.

Key skills include:

This is an important emerging direction for designers: design + code + AI-assisted development.

8. Senior UX Designer — ZS

Company: ZS
Location: New York / Hybrid
Level: Senior
Salary: $120,000–$133,000 annually

ZS is hiring a Senior User Experience Designer working on AI-powered digital products, particularly within healthcare.

The role involves leading experience strategy and collaborating with clients and cross-functional teams to develop digital healthcare solutions.

The listing specifically identifies AI, design systems, GenAI, and predictive analytics among the relevant skills.

Key skills include:

9. Senior UX/UI Designer — Modern AI

Company: Modern AI
Location: New York / Remote
Level: Senior

Modern AI is hiring a Senior UX/UI Designer for an AI-native commerce analytics platform.

The designer will work across:

The role is also described as the company's first design hire, meaning the designer would have significant responsibility for shaping both product experience and the company's broader design direction.

Key skills include:

10. UX / UI Designer — Ramsey Theory Group

Company: Ramsey Theory Group
Location: New York / Hybrid
Level: Senior
Salary: $110,000–$130,000 annually

Ramsey Theory Group is hiring a UX/UI Designer for products involving artificial intelligence, machine learning, software, and databases.

The role includes user research, user-flow design, prototyping, and collaboration on UX strategy for web and mobile platforms.

Key skills include:

The position demonstrates that AI-related design opportunities aren't limited to specialized AI Designer titles. Traditional UX/UI roles can also sit directly inside AI and machine-learning companies